Editor in Chief: Sameh S. Ali - Egypt

 

Editorial Board  

Hemal H. Patel, PhD

Professor and Vice-Chair for Research

Department of Anesthesiology

Biography

Dr. Patel was born in 1975 in India and moved to the United States at the age of 6 and grew up in the Midwest, mostly in the Chicago area. In 1998 he obtained dual bachelor’s degrees in Biology and Philosophy & Religion from Truman State University. In 1999 he began graduate studies in the Department of Pharmacology  & Toxicology at the Medical College of Wisconsin under the mentorship of Dr. Garrett Gross, a world-renowned cardiac physiologist/pharmacologist. There he developed an interest in cardiac physiology and mechanism to protect the heart from ischemic injury. In 2002 he began a post-doctoral fellowship in the Department of Pharmacology at the University of California, San Diego (UCSD) under the mentorship of Dr. Paul Insel, an expert in GPCR signaling and microdomains. Under Dr. Insel and other formative mentors at UCSD, Dr. Patel began to develop an interest and curiosity in cell biology and in particular the subcellular microdomain organization of cells that regulates physiology. He quickly developed independence and started investigating the various cellular roles for caveolin. His research has expanded to explore a variety of areas including ischemia-reperfusion injury, heart failure, diabetic cardiomyopathy, cardiac aging, neuroscience, and cancer. He currently is a Full Professor in the Department of Anesthesiology at UCSD and serves as Director of the UCSD Cardiac/Neuro Protection Laboratories and Vice Chair for Research.

 

James Brown, PhD

 Senior Lecturer at Aston University, UK

 

Dr Brown is a Senior Lecturer at Aston University, UK, working across a number of fields including ageing, obesity and metabolism and type 2 diabetes. He is currently the Director of the Aston Research Centre for Healthy Ageing (ARCHA) and a trustee and Board member of the British Society for research on Ageing (BSRA).

 

Brian P. Head, MS, PhD

Associate Professor

Research Scientist VASDHS

Department of Anesthesiology UCSD

Biography

A Research Health Scientist at the VA San Diego Healthcare System and hold a dual appointment as an Associate Professor in the Department of Anesthesiology at UCSD. The goal of my research is to use genetic interventions to restore functional neuronal and synaptic plasticity in the neurodegenerative brain and spinal cord.  Specifically, I research caveolin (Cav), a scaffolding protein in membrane/lipid rafts (MLRs), that regulates synaptic signaling and neuroplasticity in neuronal models (human neurons derived from iPSCs, animal models of neurodegeneration such as AD and ALS).  I previously published that neuron-targeted Cav-1 (using a synapsin promoter, termed SynCav1) increases MLR formation, enhances structural and functional synaptic and neuroplasticity, and improves hippocampal-dependent learning and memory in aged mice.  Recently at San Diego VA Research Week (May 14-18, 2018) symposium and workshop “InnoVAtions in Gene Therapy", I was invited to present my work titled “Neuron-targeted caveolin-1 as a gene therapy for CNS disorders”.  This InnoVAtions in Gene Therapy forum is a component of the broader National VA Research Week “InnoVAtion to Implementation” that highlighted the importance of quickly moving results from the laboratory to clinical practice in order to benefit our Veterans, which fulfills the VA mission statement and is a major objective of Chief Research and Development Officer Dr. Rachel Ramoni.  This current RR&D application addresses a major gap in knowledge that is of particular relevance to augmenting neuroplasticity and restoring neuronal function in the setting of neurodegenerative diseases such as ALS.  Outside of my research commitment, I serve as a member on the VA IACUC and R&D committees.  I actively mentor visiting international scholars who are involved in research in the laboratory here at the VA and with our affiliate university UCSD.  In 2012, I was bestowed the Presidential Early Career Awards for Scientists and Engineers (PECASE) through the Department of Veterans Affairs, which is the highest honor given by the United States Government to science and engineering professionals in the early stages of their independent research careers.